Active transport of vesicles in neurons is modulated by mechanical tension

Wylie W. Ahmed, M Taher A Saif

Research output: Contribution to journalArticle

Abstract

Effective intracellular transport of proteins and organelles is critical in cells, and is especially important for ensuring proper neuron functionality. In neurons, most proteins are synthesized in the cell body and must be transported through thin structures over long distances where normal diffusion is insufficient. Neurons transport subcellular cargo along axons and neurites through a stochastic interplay of active and passive transport. Mechanical tension is critical in maintaining proper function in neurons, but its role in transport is not well understood. To this end, we investigate the active and passive transport of vesicles in Aplysia neurons while changing neurite tension via applied strain, and quantify the resulting dynamics. We found that tension in neurons modulates active transport of vesicles by increasing the probability of active motion, effective diffusivity, and induces a retrograde bias. We show that mechanical tension modulates active transport processes in neurons and that external forces can couple to internal (subcellular) forces and change the overall transport dynamics.

Original languageEnglish (US)
Article number4481
JournalScientific Reports
Volume4
DOIs
StatePublished - Mar 27 2014

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Transport Vesicles
Active Biological Transport
Neurons
Neurites
Aplysia
Organelles
Axons
Carrier Proteins

ASJC Scopus subject areas

  • General

Cite this

Active transport of vesicles in neurons is modulated by mechanical tension. / Ahmed, Wylie W.; Saif, M Taher A.

In: Scientific Reports, Vol. 4, 4481, 27.03.2014.

Research output: Contribution to journalArticle

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