Abstract

Overproduced reactive oxygen species (ROS) are closely related to various health problems including inflammation, infection, and cancer. Abnormally high ROS levels can cause serious oxidative damage to biomolecules, cells, and tissues. A series of nano- or microsized particles has been developed to reduce the oxidative stress level by delivering antioxidant drugs. However, most systems are often plagued by slow molecular discharge, driven by diffusion. Herein, this study demonstrates the polymeric particles whose internal pressure can increase upon exposure to H 2 O 2 , one of the ROS, and in turn, discharge antioxidants actively. The on-demand pressurized particles are assembled by simultaneously encapsulating water-dispersible manganese oxide (MnO 2 ) nanosheets and green tea derived epigallocatechin gallate (EGCG) molecules into a poly(lactic-co-glycolic acid) (PLGA) spherical shell. In the presence of H 2 O 2 , the MnO 2 nanosheets in the PLGA particle generate oxygen gas by decomposing H 2 O 2 and increase the internal pressure. The pressurized PLGA particles release antioxidative EGCG actively and, in turn, protect vascular and brain tissues from oxidative damage more effectively than the particles without MnO 2 nanosheets. This H 2 O 2 responsive, self-pressurizing particle system would be useful to deliver a wide array of molecular cargos in response to the oxidation level.

Original languageEnglish (US)
Pages (from-to)35642-35650
Number of pages9
JournalACS Applied Materials and Interfaces
Volume9
Issue number41
DOIs
StatePublished - Oct 18 2017

Fingerprint

Nanosheets
Reactive Oxygen Species
Oxygen
Antioxidants
Tissue
Acids
Oxidative stress
Pressurization
Biomolecules
Medical problems
Manganese oxide
Brain
Gases
Oxidation
Molecules
Water
Pharmaceutical Preparations
polylactic acid-polyglycolic acid copolymer
Milk
epigallocatechin gallate

Keywords

  • MnO nanosheets
  • epigallocatechin gallate (EGCG)
  • hydrogen peroxide (H O )
  • oxidative damage
  • poly(lactic-co-glycolic acid) (PLGA) particle

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release. / Seo, Yongbeom; Leong, Jiayu; Teo, Jye Yng; Mitchell, Jennifer W.; Gillette, Martha L; Han, Bumsoo; Lee, Jonghwi; Kong, Hyun Joon.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 41, 18.10.2017, p. 35642-35650.

Research output: Contribution to journalArticle

Seo, Yongbeom ; Leong, Jiayu ; Teo, Jye Yng ; Mitchell, Jennifer W. ; Gillette, Martha L ; Han, Bumsoo ; Lee, Jonghwi ; Kong, Hyun Joon. / Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release. In: ACS Applied Materials and Interfaces. 2017 ; Vol. 9, No. 41. pp. 35642-35650.
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