TY - JOUR
T1 - Activation of ERα is necessary for estradiol's anorexigenic effect in female rats
AU - Santollo, Jessica
AU - Katzenellenbogen, Benita S.
AU - Katzenellenbogen, John A.
AU - Eckel, Lisa A.
N1 - Funding Information:
This work was supported by grants from the NIH : NS-062667 (JS), CA-018119 (BSK), DK-015556 (JAK), and DK-073936 (LAE).
PY - 2010/11
Y1 - 2010/11
N2 - While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.
AB - While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.
KW - Estradiol
KW - Estrogen receptor
KW - Estrous cycle
KW - Food intake
KW - MPrP
KW - PHTPP
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U2 - 10.1016/j.yhbeh.2010.08.012
DO - 10.1016/j.yhbeh.2010.08.012
M3 - Article
C2 - 20807534
AN - SCOPUS:78349307209
SN - 0018-506X
VL - 58
SP - 872
EP - 877
JO - Hormones and Behavior
JF - Hormones and Behavior
IS - 5
ER -