Activation mechanism of the human Smoothened receptor

Keyphrases

• Activation Mechanism 100%
• Smoothened Receptor 100%
• Transmembrane Domain 60%
• Receptor Activation 40%
• G Protein-coupled Receptor 40%
• Molecular Dynamics Simulation 20%
• Membrane Protein 20%
• Conformational Change 20%
• Model Theory 20%
• Level Transition 20%
• Homeostasis 20%
• Cholesterol 20%
• Transmembrane Helix 20%
• Intracellular Signaling 20%
• Cellular Differentiation 20%
• Molecular Switches 20%
• Markov State Model 20%
• Cysteine-rich Domain 20%
• Stage-wise 20%
• Static View 20%
• Residue Level 20%
• Hydrophobic Tunnel 20%
• Cholesterol Transport 20%

Biochemistry, Genetics and Molecular Biology

• Agonist 100%
• Transmembrane Domain 100%
• G Protein Coupled Receptor 66%
• Transmembrane Protein 33%
• Cellular Differentiation 33%
• Homeostasis 33%
• Conformation 33%
• Conformational Change 33%
• Membrane Protein 33%
• Cholesterol Transport 33%
• Intracellular Signaling 33%
• Cysteine 33%