Activating Metal Sites for Biological Electron Transfer

Edward I. Solomon, Ryan G. Hadt, Benjamin E.R. Snyder

Research output: Contribution to journalReview articlepeer-review


This review focuses on the unique spectroscopic features of the blue copper active sites. These reflect a novel electronic structure that activates the site for rapid long-range electron transfer in its biological function. The role of the protein in determining the geometric and electronic structure of this site is defined, as is its contribution to function. This has been referred to as the entatic/rack-induced state. These concepts are then extended to cytochrome c, which is also determined to be in an entatic state.

Original languageEnglish (US)
Pages (from-to)649-659
Number of pages11
JournalIsrael Journal of Chemistry
Issue number9-10
StatePublished - Oct 1 2016
Externally publishedYes


  • blue copper
  • cytochromes
  • electron transfer
  • structure-activity relationships
  • transition metal spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)


Dive into the research topics of 'Activating Metal Sites for Biological Electron Transfer'. Together they form a unique fingerprint.

Cite this