@inproceedings{ec2bdd66bb0a4f5bbf5418945545afcc,
title = "Acoustic fingerprints of photoacoustic contrast agents for molecular imaging",
abstract = "Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.",
keywords = "Contrast agents, Molecular imaging, Optoacoustic, Photoacoustic, Protein nanospheres, Ultrasound",
author = "McDonald, {Michael A.} and Ladislav Jankovic and Khalid Shahzad and Michael Burcher and Li, {King C}",
year = "2007",
month = apr
day = "30",
doi = "10.1117/12.702355",
language = "English (US)",
isbn = "081946550X",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics ; Conference date: 21-01-2007 Through 24-01-2007",
}