Acoustic fingerprints of photoacoustic contrast agents for molecular imaging

Michael A. McDonald, Ladislav Jankovic, Khalid Shahzad, Michael Burcher, King C Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOIs
StatePublished - Apr 30 2007
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6437
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
CountryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Keywords

  • Contrast agents
  • Molecular imaging
  • Optoacoustic
  • Photoacoustic
  • Protein nanospheres
  • Ultrasound

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    McDonald, M. A., Jankovic, L., Shahzad, K., Burcher, M., & Li, K. C. (2007). Acoustic fingerprints of photoacoustic contrast agents for molecular imaging. In Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics [64370L] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437). https://doi.org/10.1117/12.702355