Acoustic-based chemical tools for profiling the tumor microenvironment

Anuj K. Yadav, Selena Hernandez, Shengzhang Su, Jefferson Chan

Research output: Contribution to journalReview articlepeer-review

Abstract

Acoustic-based imaging modalities (e.g. ultrasonography and photoacoustic imaging) have emerged as powerful approaches to noninvasively visualize the interior of the body due to their biocompatibility and the ease of sound transmission in tissue. These technologies have recently been augmented with an array of chemical tools that enable the study and modulation of the tumor microenvironment at the molecular level. In addition, the application of ultrasound and ultrasound-responsive materials has been used for drug delivery with high spatiotemporal control. In this review, we highlight recent advances (in the last 2–3 years) in acoustic-based chemical tools and technologies suitable for furthering our understanding of molecular events in complex tumor microenvironments.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume57
DOIs
StatePublished - Aug 2020

Keywords

  • Acoustogenic probes
  • Drug delivery
  • Molecular imaging
  • Photoacoustic imaging
  • Tumor microenvironment
  • Ultrasonography
  • Ultrasound bubbles
  • Ultrasound-responsive materials

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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