Acid-sensitive magnetic nanoparticles as potential drug depots

Shy Chyi Wuang, Koon Gee Neoh, En Tang Kang, Deborah E. Leckband, Daniel W. Pack

Research output: Contribution to journalArticle

Abstract

Superparamagnetic magnetic nanoparticles were successfully functionalized with poly(methacrylic acid) via atom transfer radical polymerization, followed by conjugation to doxorubicin (Dox). Because of pH-sensitive hydrazone linkages, the rate and extent of Dox release from the particles was higher at a lower pH and/or a higher temperature than at physiological conditions. Appropriate changes to the pH and temperature can increase the drug release from the particles. Because of the released drug, the particles were found to be cytotoxic to human breast cancer cells in vitro. Such magnetic nanoparticles, with the potential to retain drug under physiological conditions and release the drug in conditions where the pH is lower or temperature is higher, may be useful in magnetic drug targeting by reducing the side effects of the drug caused to healthy tissues. In addition, they may serve as hyperthermia agents where the high temperatures used in hyperthermia can trigger further drug release.

Original languageEnglish (US)
Pages (from-to)1638-1645
Number of pages8
JournalAIChE Journal
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Nanoparticles
Temperature
Acids
Pharmaceutical Preparations
Doxorubicin
Fever
Hydrazones
Atom transfer radical polymerization
Drug Delivery Systems
Drug-Related Side Effects and Adverse Reactions
Polymerization
Cells
Tissue
Breast Neoplasms
Drug Liberation

Keywords

  • Cancer cells
  • Conjugation
  • Doxorubicin
  • Hydrazone linkages
  • Magnetic drug targeting
  • Magnetic nanoparticles
  • Poly(methacrylic acid)

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Biotechnology
  • Environmental Engineering

Cite this

Wuang, S. C., Neoh, K. G., Kang, E. T., Leckband, D. E., & Pack, D. W. (2011). Acid-sensitive magnetic nanoparticles as potential drug depots. AIChE Journal, 57(6), 1638-1645. https://doi.org/10.1002/aic.12373

Acid-sensitive magnetic nanoparticles as potential drug depots. / Wuang, Shy Chyi; Neoh, Koon Gee; Kang, En Tang; Leckband, Deborah E.; Pack, Daniel W.

In: AIChE Journal, Vol. 57, No. 6, 01.06.2011, p. 1638-1645.

Research output: Contribution to journalArticle

Wuang, SC, Neoh, KG, Kang, ET, Leckband, DE & Pack, DW 2011, 'Acid-sensitive magnetic nanoparticles as potential drug depots', AIChE Journal, vol. 57, no. 6, pp. 1638-1645. https://doi.org/10.1002/aic.12373
Wuang, Shy Chyi ; Neoh, Koon Gee ; Kang, En Tang ; Leckband, Deborah E. ; Pack, Daniel W. / Acid-sensitive magnetic nanoparticles as potential drug depots. In: AIChE Journal. 2011 ; Vol. 57, No. 6. pp. 1638-1645.
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