Achieving and maintaining cognitive vitality with aging

Howard M. Fillit, Robert N. Butler, Alan W. O’Connell, Marilyn S. Albert, James E. Birren, Carl W. Cotman, William T. Greenough, Paul E. Gold, Arthur F Kramer, Lewis H. Kuller, Thomas T. Perls, Barbara G. Sahagan, Tim Tully

Research output: Contribution to journalReview article

Abstract

Cognitive vitality is essential to quality of life and survival in old age. With normal aging, cognitive changes such as slowed speed of processing are common, but there is substantial interindividual variability, and cognitive decline is clearly not inevitable. In this review, we focus on recent research investigating the association of various lifestyle factors and medical comorbidities with cognitive aging. Most of these factors are potentially modifiable or manageable, and some are protective. For example, animal and human studies suggest that lifelong learning, mental and physical exercise, continuing social engagement, stress reduction, and proper nutrition may be important factors in promoting cognitive vitality in aging. Manageable medical comorbidities, such as diabetes, hypertension, and hyperlipidemia, also contribute to cognitive decline in older persons. Other comorbidities such as smoking and excess alcohol intake may contribute to cognitive decline, and avoiding these activities may promote cognitive vitality in aging. Various therapeutics, including cognitive enhancers and protective agents such as antioxidants and anti-inflammatories, may eventually prove useful as adjuncts for the prevention and treatment of cognitive decline with aging. The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging.

Original languageEnglish (US)
Pages (from-to)681-696
Number of pages16
JournalMayo Clinic Proceedings
Volume77
Issue number7
DOIs
StatePublished - Jan 1 2002

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Comorbidity
Nootropic Agents
Protective Agents
Preventive Medicine
Hyperlipidemias
Life Style
Anti-Inflammatory Agents
Antioxidants
Smoking
Alcohols
Quality of Life
Learning
Exercise
Hypertension
Physicians
Survival
Cognitive Dysfunction
Therapeutics
Research
Cognitive Aging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fillit, H. M., Butler, R. N., O’Connell, A. W., Albert, M. S., Birren, J. E., Cotman, C. W., ... Tully, T. (2002). Achieving and maintaining cognitive vitality with aging. Mayo Clinic Proceedings, 77(7), 681-696. https://doi.org/10.4065/77.7.681

Achieving and maintaining cognitive vitality with aging. / Fillit, Howard M.; Butler, Robert N.; O’Connell, Alan W.; Albert, Marilyn S.; Birren, James E.; Cotman, Carl W.; Greenough, William T.; Gold, Paul E.; Kramer, Arthur F; Kuller, Lewis H.; Perls, Thomas T.; Sahagan, Barbara G.; Tully, Tim.

In: Mayo Clinic Proceedings, Vol. 77, No. 7, 01.01.2002, p. 681-696.

Research output: Contribution to journalReview article

Fillit, HM, Butler, RN, O’Connell, AW, Albert, MS, Birren, JE, Cotman, CW, Greenough, WT, Gold, PE, Kramer, AF, Kuller, LH, Perls, TT, Sahagan, BG & Tully, T 2002, 'Achieving and maintaining cognitive vitality with aging', Mayo Clinic Proceedings, vol. 77, no. 7, pp. 681-696. https://doi.org/10.4065/77.7.681
Fillit HM, Butler RN, O’Connell AW, Albert MS, Birren JE, Cotman CW et al. Achieving and maintaining cognitive vitality with aging. Mayo Clinic Proceedings. 2002 Jan 1;77(7):681-696. https://doi.org/10.4065/77.7.681
Fillit, Howard M. ; Butler, Robert N. ; O’Connell, Alan W. ; Albert, Marilyn S. ; Birren, James E. ; Cotman, Carl W. ; Greenough, William T. ; Gold, Paul E. ; Kramer, Arthur F ; Kuller, Lewis H. ; Perls, Thomas T. ; Sahagan, Barbara G. ; Tully, Tim. / Achieving and maintaining cognitive vitality with aging. In: Mayo Clinic Proceedings. 2002 ; Vol. 77, No. 7. pp. 681-696.
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