Acetohydroxy acid synthase I is required for isoleucine and valine biosynthesis by Salmonella typhimurium LT2 during growth on acetate or long-chain fatty acids

F. E. Dailey, J. E. Cronan, S. R. Maloy

Research output: Contribution to journalArticle

Abstract

Salmonella typhimurium LT2 normally expresses two acetohydroxy acid synthases (AHAS I and AHAS II). The function of AHAS I in this organism was unclear, since AHAS I-deficient (ilvBN) mutants of LT2 grew well on glucose or succinate minimal media, whereas AHAS II-deficient (ilvGM) mutants required isoleucine for normal growth on glucose minimal media. We report that AHAS I-deficient mutants of S. typhimurium required isoleucine and valine for growth on acetate or oleate minimal media, whereas AHAS II-deficient mutants were able to grow on these media without isoleucine supplementation.

Original languageEnglish (US)
Pages (from-to)917-919
Number of pages3
JournalJournal of bacteriology
Volume169
Issue number2
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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