Abstract
Westheimer's classical proposal that the decreased pKa of Lys115 in the active site of acetoacetate decarboxylase is the result of its unfavorable electrostatic juxtaposition with Lys116 has been evaluated by X-ray crystallography. The long-awaited structure reveals that Lys115 is positioned in a hydrophobic pocket that lowers its pKa.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 454-455 |
| Number of pages | 2 |
| Journal | Nature chemical biology |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2009 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology