Acetoacetate decarboxylase: Hydrophobics, not electrostatics

Research output: Contribution to journalShort surveypeer-review


Westheimer's classical proposal that the decreased pKa of Lys115 in the active site of acetoacetate decarboxylase is the result of its unfavorable electrostatic juxtaposition with Lys116 has been evaluated by X-ray crystallography. The long-awaited structure reveals that Lys115 is positioned in a hydrophobic pocket that lowers its pKa.

Original languageEnglish (US)
Pages (from-to)454-455
Number of pages2
JournalNature chemical biology
Issue number7
StatePublished - Jul 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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