TY - JOUR
T1 - Accelerometer measured physical activity and the integrity of the anterior visual pathway in multiple sclerosis
AU - Sandroff, Brian M.
AU - Motl, Robert W.
AU - Kam, Jason P.
AU - Pula, John H.
N1 - Funding Information:
Data from this study were presented as an abstract at the 2012 Consortium of Multiple Sclerosis Centers Annual Meeting in Montreal, QC, Canada. The research was funded by a grant from OSF Hospital, Peoria , IL that was awarded to Dr. John Pula.
Funding Information:
This project was funded by a grant from the OSF Foundation.
PY - 2014/1
Y1 - 2014/1
N2 - Purpose To examine the associations among objectively-measured physical activity with the optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with multiple sclerosis (MS). Methods Eighty four participants with MS, without ocular disease or high myopia underwent a neurological examination for Expanded Disability Status Scale (EDSS) scoring, followed by OCT. Participants then wore an accelerometer during the waking hours of a 7-day period to objectively measure physical activity as steps/day. Results Mean RNFL thickness for the sample was 91.46 μm (SD=15.0), and mean TMV was 6.61 mm3 (SD=0.5). The mean score from the accelerometer was 4287 steps/day (SD=2563). Steps/day was significantly associated with both RNFL thickness (Wald χ2= 46.48, p<0.001) and TMV (Wald χ2=1798.27, p<0.001). After controlling for sex, MS subtype, disease duration, disability, and visual function, steps/day was significantly associated with TMV (Wald χ2=58.93, p<0.001), but not RNFL (Wald χ2=0. 001, p=0.973). Conclusions Physical activity was associated with integrity of the anterior visual pathway, assessed by OCT, in persons with MS, and this association was independent of sex, MS subtype, disease duration, disability, and visual function. Researchers should consider examining the causal nature of the association between physical activity and markers of the visual system in MS.
AB - Purpose To examine the associations among objectively-measured physical activity with the optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with multiple sclerosis (MS). Methods Eighty four participants with MS, without ocular disease or high myopia underwent a neurological examination for Expanded Disability Status Scale (EDSS) scoring, followed by OCT. Participants then wore an accelerometer during the waking hours of a 7-day period to objectively measure physical activity as steps/day. Results Mean RNFL thickness for the sample was 91.46 μm (SD=15.0), and mean TMV was 6.61 mm3 (SD=0.5). The mean score from the accelerometer was 4287 steps/day (SD=2563). Steps/day was significantly associated with both RNFL thickness (Wald χ2= 46.48, p<0.001) and TMV (Wald χ2=1798.27, p<0.001). After controlling for sex, MS subtype, disease duration, disability, and visual function, steps/day was significantly associated with TMV (Wald χ2=58.93, p<0.001), but not RNFL (Wald χ2=0. 001, p=0.973). Conclusions Physical activity was associated with integrity of the anterior visual pathway, assessed by OCT, in persons with MS, and this association was independent of sex, MS subtype, disease duration, disability, and visual function. Researchers should consider examining the causal nature of the association between physical activity and markers of the visual system in MS.
KW - Accelerometers
KW - Imaging
KW - Multiple sclerosis
KW - Optical coherence tomography
KW - Physical activity
KW - Total macular volume
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U2 - 10.1016/j.msard.2013.06.014
DO - 10.1016/j.msard.2013.06.014
M3 - Article
AN - SCOPUS:84884291544
SN - 2211-0348
VL - 3
SP - 117
EP - 122
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
IS - 1
ER -