Accelerating T2 mapping of the brain by integrating deep learning priors with low-rank and sparse modeling

Ziyu Meng, Rong Guo, Yudu Li, Yue Guan, Tianyao Wang, Yibo Zhao, Brad Sutton, Yao Li, Zhi-Pei Liang

Research output: Contribution to journalArticlepeer-review


PURPOSE: To accelerate T2 mapping with highly sparse sampling by integrating deep learning image priors with low-rank and sparse modeling.

METHODS: The proposed method achieves high-speed T2 mapping by highly sparsely sampling (k, TE)-space. Image reconstruction from the undersampled data was done by exploiting the low-rank structure and sparsity in the T2 -weighted image sequence and image priors learned from training data. The image priors for a single TE were generated from the public Human Connectome Project data using a tissue-based deep learning method; the image priors were then transferred to other TEs using a generalized series-based method. With these image priors, the proposed reconstruction method used a low-rank model and a sparse model to capture subject-dependent novel features.

RESULTS: The proposed method was evaluated using experimental data obtained from both healthy subjects and tumor patients using a turbo spin-echo sequence. High-quality T2 maps at the resolution of 0.9 × 0.9 × 3.0 mm3 were obtained successfully from highly undersampled data with an acceleration factor of 8. Compared with the existing compressed sensing-based methods, the proposed method produced significantly reduced reconstruction errors. Compared with the deep learning-based methods, the proposed method recovered novel features better.

CONCLUSION: This paper demonstrates the feasibility of learning T2 -weighted image priors for multiple TEs using tissue-based deep learning and generalized series-based learning. A new method was proposed to effectively integrate these image priors with low-rank and sparse modeling to reconstruct high-quality images from highly undersampled data. The proposed method will supplement other acquisition-based methods to achieve high-speed T2 mapping.

Original languageEnglish (US)
Pages (from-to)1455-1467
Number of pages13
JournalMagnetic Resonance in Medicine
Issue number3
Early online dateSep 29 2020
StatePublished - Mar 2021


  • deep learning
  • low-rank modeling
  • quantitative imaging
  • sparse modeling
  • T mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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