TY - JOUR
T1 - Absorption and retention of aluminum from drinking water
T2 - 1. Effect of citric and ascorbic acids on aluminum tissue levels in rabbits
AU - Fulton, Barbara
AU - Jeffery, Elizabeth H.
N1 - Funding Information:
This work was supported by Grant S-120 from the Water Resource Center (U.S. Geological Survey). The authors thank Dr. J. Alho for his discussion on statistical evaluation of the data. and T. Dikici, B. Lewis, Y. Pang, and E. Wang for performing the analyses.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 1990/5
Y1 - 1990/5
N2 - Absorption and Retention of Aluminum from Drinking Water. 1. Effect of Citric and Ascorbic Acids on Aluminum Tissue Levels in Rabbits. FULTON, B., AND JEFFERY, E. H. (1990). Fundam. Appl. Toxicol. 14, 788-796. Adult, male New Zealand rabbits (three per group) were administered drinking water containing aluminum chloride (0, 100, or 500 mg Al/liter) together with citrate (0.11 m), ascorbate (0.11 M), or no added ligand ad libitum for 12 weeks. They were fed ad libitum regular rabbit chow analyzed to contain 297 mg Al/kg. Treatment had no effect upon food and water intake or weight gain during the experimental period. No effect of aluminum was observed on tissue levels of the essential metals zinc, copper, and iron, or on hemoglobin and hematocrit values. Aluminum levels were found to increase in a dose-dependent manner in stomach and intestinal mucosa, kidney, bone, urine, and feces. There was only a slight accumulation in liver, and no accumulation in brain (cerebral cortex or hippocampus). Although plasma aluminum was directly related to aluminum intake, whole blood aluminum bore no relation to aluminum dose. Citrate had no effect on aluminum accumulation in the stomach or intestine, but significantly enhanced plasma and bone aluminum levels. Ascorbate did not enhance aluminum accumulation in any tissue studied and even prevented accumulation in bone. Both citrate and ascorbate enhanced excretion of aluminum. Ascorbate therapy may be of potential clinical use to enhance aluminum excretion.
AB - Absorption and Retention of Aluminum from Drinking Water. 1. Effect of Citric and Ascorbic Acids on Aluminum Tissue Levels in Rabbits. FULTON, B., AND JEFFERY, E. H. (1990). Fundam. Appl. Toxicol. 14, 788-796. Adult, male New Zealand rabbits (three per group) were administered drinking water containing aluminum chloride (0, 100, or 500 mg Al/liter) together with citrate (0.11 m), ascorbate (0.11 M), or no added ligand ad libitum for 12 weeks. They were fed ad libitum regular rabbit chow analyzed to contain 297 mg Al/kg. Treatment had no effect upon food and water intake or weight gain during the experimental period. No effect of aluminum was observed on tissue levels of the essential metals zinc, copper, and iron, or on hemoglobin and hematocrit values. Aluminum levels were found to increase in a dose-dependent manner in stomach and intestinal mucosa, kidney, bone, urine, and feces. There was only a slight accumulation in liver, and no accumulation in brain (cerebral cortex or hippocampus). Although plasma aluminum was directly related to aluminum intake, whole blood aluminum bore no relation to aluminum dose. Citrate had no effect on aluminum accumulation in the stomach or intestine, but significantly enhanced plasma and bone aluminum levels. Ascorbate did not enhance aluminum accumulation in any tissue studied and even prevented accumulation in bone. Both citrate and ascorbate enhanced excretion of aluminum. Ascorbate therapy may be of potential clinical use to enhance aluminum excretion.
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U2 - 10.1093/toxsci/14.4.788
DO - 10.1093/toxsci/14.4.788
M3 - Article
C2 - 2361577
AN - SCOPUS:77957181490
SN - 1096-6080
VL - 14
SP - 788
EP - 796
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 4
ER -