A role in thymic maturation for factors of the NF-κB family has long been suspected, but not yet proven. Transgenic mice with a lymphocyte-specific defect in NF-κB activation were produced by targeted expression of human IκBα. The thymic cellularity of these mice was significantly decreased. The proportion of mature, TCRhigh thymocytes of the αβ lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells. This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected. These data provide direct evidence for the involvement of NF-κB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Immunology and Allergy