Abnormal T lymphocyte development induced by targeted overexpression of IκBα

Christoph W. Esslinger, Anne Wilson, Bernard Sordat, Friedrich Beermann, C. Victor Jongeneel

Research output: Contribution to journalArticlepeer-review

Abstract

A role in thymic maturation for factors of the NF-κB family has long been suspected, but not yet proven. Transgenic mice with a lymphocyte-specific defect in NF-κB activation were produced by targeted expression of human IκBα. The thymic cellularity of these mice was significantly decreased. The proportion of mature, TCRhigh thymocytes of the αβ lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells. This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected. These data provide direct evidence for the involvement of NF-κB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.

Original languageEnglish (US)
Pages (from-to)5075-5078
Number of pages4
JournalJournal of Immunology
Volume158
Issue number11
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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