Ablation of atrial-ventricular junction tissues via the coronary sinus using cryo balloon technology

Boaz Avitall, Daniel Lafontaine, Grzegorz Rozmus, Naveed Adoni, Abed Dehnee, Arvydas Urbonas, Khoi M. Le, Dinas Aleksonis

Research output: Contribution to journalArticle

Abstract

Introduction: The coronary sinus (CS) can provide access to targets across and within the atrioventricular (AV) junction. Methods: In 12 dogs (32 ± 3 Kg), cryo balloons (10-19 mm) were applied to regions of the AV junction for 3 minutes at a temperature of -75.9° ± 9°C (ranging -57 to -83). Electrical activity and pacing within the CS were assessed pre and post ablation and at least 3 months later in 9 dogs. In the 3 other dogs, hearts were examined immediately after cryo ablation. CS and circumflex angiography was performed pre and post ablation. The hearts, CS, and Cx were then examined for structural injury. The AV junction was sectioned and the hearts were immersed in Tetrazolium, and the lesions were inspected for transmurality across the AV groove. Results: In 3/12 dogs the distal CS cryo lesions resulted in inferior ST segment depression that resolved within 5 minutes. There was no arrhythmia or hemodynamic changes. No CS electrical activity was noted post ablation. The pacing threshold increased from 2 ± 2.3 mA to 7.4 ± 3.6 mA (p < 0.001). Pathological examination of 3 acute hearts revealed hematomas. There was no pericardial effusion. No evidence of stenosis or thrombosis was seen within the CS and the circumflex artery. After 3 months of recovery, transmural lesions across the AV groove were present in all of the targeted AV regions. Conclusion: Intra-CS cryo balloon ablation is safe and can potentially replace endocardial RF ablation targeting the AV junction and the CS muscular sleeve.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of Interventional Cardiac Electrophysiology
Volume12
Issue number3
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Fingerprint

Coronary Sinus
Technology
Dogs
Pericardial Effusion
Hematoma
Cardiac Arrhythmias
Angiography
Pathologic Constriction
Thrombosis
Arteries
Hemodynamics
Temperature
Wounds and Injuries

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Coronary sinus
  • Cryoablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Ablation of atrial-ventricular junction tissues via the coronary sinus using cryo balloon technology. / Avitall, Boaz; Lafontaine, Daniel; Rozmus, Grzegorz; Adoni, Naveed; Dehnee, Abed; Urbonas, Arvydas; Le, Khoi M.; Aleksonis, Dinas.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 12, No. 3, 01.04.2005, p. 203-211.

Research output: Contribution to journalArticle

Avitall, Boaz ; Lafontaine, Daniel ; Rozmus, Grzegorz ; Adoni, Naveed ; Dehnee, Abed ; Urbonas, Arvydas ; Le, Khoi M. ; Aleksonis, Dinas. / Ablation of atrial-ventricular junction tissues via the coronary sinus using cryo balloon technology. In: Journal of Interventional Cardiac Electrophysiology. 2005 ; Vol. 12, No. 3. pp. 203-211.
@article{af241ee909804e64a6b1dc6cc9cd5973,
title = "Ablation of atrial-ventricular junction tissues via the coronary sinus using cryo balloon technology",
abstract = "Introduction: The coronary sinus (CS) can provide access to targets across and within the atrioventricular (AV) junction. Methods: In 12 dogs (32 ± 3 Kg), cryo balloons (10-19 mm) were applied to regions of the AV junction for 3 minutes at a temperature of -75.9° ± 9°C (ranging -57 to -83). Electrical activity and pacing within the CS were assessed pre and post ablation and at least 3 months later in 9 dogs. In the 3 other dogs, hearts were examined immediately after cryo ablation. CS and circumflex angiography was performed pre and post ablation. The hearts, CS, and Cx were then examined for structural injury. The AV junction was sectioned and the hearts were immersed in Tetrazolium, and the lesions were inspected for transmurality across the AV groove. Results: In 3/12 dogs the distal CS cryo lesions resulted in inferior ST segment depression that resolved within 5 minutes. There was no arrhythmia or hemodynamic changes. No CS electrical activity was noted post ablation. The pacing threshold increased from 2 ± 2.3 mA to 7.4 ± 3.6 mA (p < 0.001). Pathological examination of 3 acute hearts revealed hematomas. There was no pericardial effusion. No evidence of stenosis or thrombosis was seen within the CS and the circumflex artery. After 3 months of recovery, transmural lesions across the AV groove were present in all of the targeted AV regions. Conclusion: Intra-CS cryo balloon ablation is safe and can potentially replace endocardial RF ablation targeting the AV junction and the CS muscular sleeve.",
keywords = "Atrial fibrillation, Catheter ablation, Coronary sinus, Cryoablation",
author = "Boaz Avitall and Daniel Lafontaine and Grzegorz Rozmus and Naveed Adoni and Abed Dehnee and Arvydas Urbonas and Le, {Khoi M.} and Dinas Aleksonis",
year = "2005",
month = "4",
day = "1",
doi = "10.1007/s10840-005-0339-5",
language = "English (US)",
volume = "12",
pages = "203--211",
journal = "Journal of Interventional Cardiac Electrophysiology",
issn = "1383-875X",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - Ablation of atrial-ventricular junction tissues via the coronary sinus using cryo balloon technology

AU - Avitall, Boaz

AU - Lafontaine, Daniel

AU - Rozmus, Grzegorz

AU - Adoni, Naveed

AU - Dehnee, Abed

AU - Urbonas, Arvydas

AU - Le, Khoi M.

AU - Aleksonis, Dinas

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Introduction: The coronary sinus (CS) can provide access to targets across and within the atrioventricular (AV) junction. Methods: In 12 dogs (32 ± 3 Kg), cryo balloons (10-19 mm) were applied to regions of the AV junction for 3 minutes at a temperature of -75.9° ± 9°C (ranging -57 to -83). Electrical activity and pacing within the CS were assessed pre and post ablation and at least 3 months later in 9 dogs. In the 3 other dogs, hearts were examined immediately after cryo ablation. CS and circumflex angiography was performed pre and post ablation. The hearts, CS, and Cx were then examined for structural injury. The AV junction was sectioned and the hearts were immersed in Tetrazolium, and the lesions were inspected for transmurality across the AV groove. Results: In 3/12 dogs the distal CS cryo lesions resulted in inferior ST segment depression that resolved within 5 minutes. There was no arrhythmia or hemodynamic changes. No CS electrical activity was noted post ablation. The pacing threshold increased from 2 ± 2.3 mA to 7.4 ± 3.6 mA (p < 0.001). Pathological examination of 3 acute hearts revealed hematomas. There was no pericardial effusion. No evidence of stenosis or thrombosis was seen within the CS and the circumflex artery. After 3 months of recovery, transmural lesions across the AV groove were present in all of the targeted AV regions. Conclusion: Intra-CS cryo balloon ablation is safe and can potentially replace endocardial RF ablation targeting the AV junction and the CS muscular sleeve.

AB - Introduction: The coronary sinus (CS) can provide access to targets across and within the atrioventricular (AV) junction. Methods: In 12 dogs (32 ± 3 Kg), cryo balloons (10-19 mm) were applied to regions of the AV junction for 3 minutes at a temperature of -75.9° ± 9°C (ranging -57 to -83). Electrical activity and pacing within the CS were assessed pre and post ablation and at least 3 months later in 9 dogs. In the 3 other dogs, hearts were examined immediately after cryo ablation. CS and circumflex angiography was performed pre and post ablation. The hearts, CS, and Cx were then examined for structural injury. The AV junction was sectioned and the hearts were immersed in Tetrazolium, and the lesions were inspected for transmurality across the AV groove. Results: In 3/12 dogs the distal CS cryo lesions resulted in inferior ST segment depression that resolved within 5 minutes. There was no arrhythmia or hemodynamic changes. No CS electrical activity was noted post ablation. The pacing threshold increased from 2 ± 2.3 mA to 7.4 ± 3.6 mA (p < 0.001). Pathological examination of 3 acute hearts revealed hematomas. There was no pericardial effusion. No evidence of stenosis or thrombosis was seen within the CS and the circumflex artery. After 3 months of recovery, transmural lesions across the AV groove were present in all of the targeted AV regions. Conclusion: Intra-CS cryo balloon ablation is safe and can potentially replace endocardial RF ablation targeting the AV junction and the CS muscular sleeve.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Coronary sinus

KW - Cryoablation

UR - http://www.scopus.com/inward/record.url?scp=23944505567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944505567&partnerID=8YFLogxK

U2 - 10.1007/s10840-005-0339-5

DO - 10.1007/s10840-005-0339-5

M3 - Article

C2 - 15875111

AN - SCOPUS:23944505567

VL - 12

SP - 203

EP - 211

JO - Journal of Interventional Cardiac Electrophysiology

JF - Journal of Interventional Cardiac Electrophysiology

SN - 1383-875X

IS - 3

ER -