Abstract

Steady progress has been made in the field of ab initio protein folding. A variety of methods now allow the prediction of low-resolution structures of small proteins or protein fragments up to approximately 100 amino acid residues in length. Such low-resolution structures may be sufficient for the functional annotation of protein sequences on a genome-wide scale. Although no consistently reliable algorithm is currently available, the essential challenges to developing a general theory or approach to protein structure prediction are better understood. The energy landscapes resulting from the structure prediction algorithms are only partially funneled to the native state of the protein. This review focuses on two areas of recent advances in abinitio structure prediction - improvements in the energy functions and strategies to search the caldera region of the energy landscapes.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2002

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Proteins
Molecular Sequence Annotation
Protein Folding
Genome
Amino Acids

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Ab initio protein structure prediction. / Hardin, Corey; Pogorelov, Taras V; Luthey-Schulten, Zaida Ann.

In: Current Opinion in Structural Biology, Vol. 12, No. 2, 01.04.2002, p. 176-181.

Research output: Contribution to journalReview article

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