A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel

J. H. Park, A. Kim, S. H. Song, P. Bhandari, J. Irudayaraj, B. Ziaie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we demonstrate a wireless chemical sensing scheme using ultrasonic imaging of a microbubble-functionalized hydrogel, which we call 'bubblegel.' By incorporating oxygen microbubbles into a hydrogel, its volume transition, which is responsive to its chemical microenvironment, can be wirelessly monitored by ultrasonic imaging; measuring volume directly or measuring the reflected acoustic intensity from the surface of the bubblegel. Here a bubblegel fabricated with pH-sensitive poly (methacrylic acid-co-acrylamide) hydrogel is investigated in vitro. The sensor shows a sensitivity of 19.49 gray-scale intensity/pH and a resolution of 0.25 pH unit in the linear response region (between pH 4 and 6). It is expected that the concept can be adapted to hydrogels sensitive to other stimuli (e.g., glucose, biomarkers, etc.).

Original languageEnglish (US)
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2220-2223
Number of pages4
ISBN (Electronic)9781479989553
DOIs
StatePublished - Aug 5 2015
Externally publishedYes
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Publication series

Name2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period6/21/156/25/15

Fingerprint

Ultrasonic imaging
Hydrogels
ultrasonics
Acoustic intensity
biomarkers
gray scale
Biomarkers
glucose
stimuli
Glucose
acids
Oxygen
acoustics
Acids
sensitivity
sensors
Sensors
oxygen

Keywords

  • Chemical Sensor
  • Hydrogel
  • Ultrasonic Imaging

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Park, J. H., Kim, A., Song, S. H., Bhandari, P., Irudayaraj, J., & Ziaie, B. (2015). A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (pp. 2220-2223). [7181402] (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181402

A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel. / Park, J. H.; Kim, A.; Song, S. H.; Bhandari, P.; Irudayaraj, J.; Ziaie, B.

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2220-2223 7181402 (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Park, JH, Kim, A, Song, SH, Bhandari, P, Irudayaraj, J & Ziaie, B 2015, A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181402, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Institute of Electrical and Electronics Engineers Inc., pp. 2220-2223, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181402
Park JH, Kim A, Song SH, Bhandari P, Irudayaraj J, Ziaie B. A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel. In 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 2220-2223. 7181402. (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015). https://doi.org/10.1109/TRANSDUCERS.2015.7181402
Park, J. H. ; Kim, A. ; Song, S. H. ; Bhandari, P. ; Irudayaraj, J. ; Ziaie, B. / A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel. 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 2220-2223 (2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015).
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