A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel

J. H. Park, A. Kim, S. H. Song, P. Bhandari, J. Irudayaraj, B. Ziaie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we demonstrate a wireless chemical sensing scheme using ultrasonic imaging of a microbubble-functionalized hydrogel, which we call 'bubblegel.' By incorporating oxygen microbubbles into a hydrogel, its volume transition, which is responsive to its chemical microenvironment, can be wirelessly monitored by ultrasonic imaging; measuring volume directly or measuring the reflected acoustic intensity from the surface of the bubblegel. Here a bubblegel fabricated with pH-sensitive poly (methacrylic acid-co-acrylamide) hydrogel is investigated in vitro. The sensor shows a sensitivity of 19.49 gray-scale intensity/pH and a resolution of 0.25 pH unit in the linear response region (between pH 4 and 6). It is expected that the concept can be adapted to hydrogels sensitive to other stimuli (e.g., glucose, biomarkers, etc.).

Original languageEnglish (US)
Title of host publication2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2220-2223
Number of pages4
ISBN (Electronic)9781479989553
DOIs
StatePublished - Aug 5 2015
Externally publishedYes
Event18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, United States
Duration: Jun 21 2015Jun 25 2015

Publication series

Name2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Other

Other18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
CountryUnited States
CityAnchorage
Period6/21/156/25/15

Keywords

  • Chemical Sensor
  • Hydrogel
  • Ultrasonic Imaging

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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