A unique signature identifies a family of zinc-dependent metallopeptidases

C. Victor Jongeneel; Jacques Bouvier; Amos Bairoch

doi:10.1016/0014-5793(89)80471-5

A unique signature identifies a family of zinc-dependent metallopeptidases

C. Victor Jongeneel, Jacques Bouvier, Amos Bairoch

Research output: Contribution to journal › Article › peer-review

Abstract

The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

Original language	English (US)
Pages (from-to)	211-214
Number of pages	4
Journal	FEBS Letters
Volume	242
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80471-5
State	Published - Jan 2 1989
Externally published	Yes

Keywords

Amino acid sequence
Information system
Metalloproteinase
Zinc

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Online availability

10.1016/0014-5793(89)80471-5

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title = "A unique signature identifies a family of zinc-dependent metallopeptidases",

abstract = "The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.",

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language = "English (US)",

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AU - Jongeneel, C. Victor

AU - Bouvier, Jacques

AU - Bairoch, Amos

PY - 1989/1/2

Y1 - 1989/1/2

N2 - The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

AB - The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

KW - Amino acid sequence

KW - Information system

KW - Metalloproteinase

KW - Zinc

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ER -

A unique signature identifies a family of zinc-dependent metallopeptidases

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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