A unique signature identifies a family of zinc-dependent metallopeptidases

C. Victor Jongeneel, Jacques Bouvier, Amos Bairoch

Research output: Contribution to journalArticlepeer-review


The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalFEBS Letters
Issue number2
StatePublished - Jan 2 1989
Externally publishedYes


  • Amino acid sequence
  • Information system
  • Metalloproteinase
  • Zinc

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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