A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Marimuthu Jeya; Tae Su Kim; Manish Kumar Tiwari; Jinglin Li; Huimin Zhao; Jung Kul Lee

doi:10.1039/c2mb25347j

A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Marimuthu Jeya
, Tae Su Kim
, Manish Kumar Tiwari
, Jinglin Li
, Huimin Zhao
, Jung Kul Lee

Research output: Contribution to journal › Article › peer-review

Abstract

A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (k_cat/K_m = 5230 mM^-1 min^-1) for malonyl CoA was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS. This journal is

Original language	English (US)
Pages (from-to)	3103-3106
Number of pages	4
Journal	Molecular BioSystems
Volume	8
Issue number	12
DOIs	https://doi.org/10.1039/c2mb25347j
State	Published - Dec 2012

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Biotechnology
Molecular Biology

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10.1039/c2mb25347j

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abstract = "A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (kcat/Km = 5230 mM-1 min-1) for malonyl CoA was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS. This journal is",

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AU - Kim, Tae Su

AU - Kumar Tiwari, Manish

AU - Li, Jinglin

AU - Zhao, Huimin

AU - Lee, Jung Kul

PY - 2012/12

Y1 - 2012/12

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AB - A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (kcat/Km = 5230 mM-1 min-1) for malonyl CoA was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS. This journal is

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A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

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