A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Marimuthu Jeya, Tae Su Kim, Manish Kumar Tiwari, Jinglin Li, Huimin Zhao, Jung Kul Lee

Research output: Contribution to journalArticlepeer-review

Abstract

A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (kcat/Km = 5230 mM-1 min-1) for malonyl CoA was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS. This journal is

Original languageEnglish (US)
Pages (from-to)3103-3106
Number of pages4
JournalMolecular BioSystems
Volume8
Issue number12
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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