A transient excited state model for sodium permeability changes in excitable membranes

E. Jakobsson, C. Scudiero

Research output: Contribution to journalArticle

Abstract

In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.

Original languageEnglish (US)
Pages (from-to)577-590
Number of pages14
JournalBiophysical journal
Volume15
Issue number6
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Biophysics

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