Abstract
In this paper we explore the properties of a mathematical model for the passive sodium permeability system of excitable membranes. This model is distinguished by the explicit inclusion of a rate constant which depends not on instantaneous voltage, but on rate of voltage change. Actually, the model is a rather modest modification of the Hodgkin-Huxley model, but displays some behaviors which the H-H model does not. Among these behaviors are a pronounced inactivation shift (for certain parameter values), a difference between inactivation time constant as measured by turning off a sodium current under sustained depolarization and as measured by double pulse experiments, skip runs under sustained current stimulation, and accommodation to slowing rising currents.
Original language | English (US) |
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Pages (from-to) | 577-590 |
Number of pages | 14 |
Journal | Biophysical journal |
Volume | 15 |
Issue number | 6 |
DOIs | |
State | Published - 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics