A transaldolase-dependent sulfoglycolysis pathway in Bacillus megaterium DSM 1804

Yinbo Liu, Yifeng Wei, Yan Zhou, Ee Lui Ang, Huimin Zhao, Yan Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Sulfoquinovose (6-deoxy-6-sulfoglucose, SQ) is a component of sulfolipids found in the photosynthetic membranes of plants and other photosynthetic organisms, and is one of the most abundant organosulfur compounds in nature. Microbial degradation of SQ, termed sulfoglycolysis, constitutes an important component of the biogeochemical sulfur cycle. Two sulfoglycolysis pathways have been reported, with one resembling the Embden–Meyerhof–Parnas (sulfo-EMP) pathway, and the other resembling the Entner–Doudoroff (sulfo-ED) pathway. Here we report a third sulfoglycolysis pathway in the bacterium Bacillus megaterium DSM 1804, in which sulfosugar cleavage is catalyzed by the transaldolase SqvA, which converts 6-deoxy-6-sulfofructose and glyceraldehyde 3-phosphate into fructose -6-phosphate and (S)-sulfolactaldehyde. Variations of this transaldolase-dependent sulfoglycolysis (sulfo-TAL) pathway are present in diverse bacteria, and add to the diversity of mechanisms for the degradation of this abundant organosulfur compound.

Original languageEnglish (US)
Pages (from-to)1109-1114
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume533
Issue number4
DOIs
StatePublished - Dec 17 2020

Keywords

  • Sulfoglycolysis
  • Sulfoquinovose
  • Sulfur cycle
  • Transaldolase

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Cell Biology

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