A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

Haruo Saito, David M. Kranz, Yohtaroh Takagaki, Adrian C. Hayday, Herman N. Eisen, Susumu Tonegawa

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Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalNature
Volume312
Issue number5989
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

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Saito, H., Kranz, D. M., Takagaki, Y., Hayday, A. C., Eisen, H. N., & Tonegawa, S. (1984). A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature, 312(5989), 36-40. https://doi.org/10.1038/312036a0