A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

Haruo Saito, David M Kranz, Yohtaroh Takagaki, Adrian C. Hayday, Herman N. Eisen, Susumu Tonegawa

Research output: Contribution to journalArticle

Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalNature
Volume312
Issue number5989
DOIs
StatePublished - Dec 1 1984
Externally publishedYes

Fingerprint

Cytotoxic T-Lymphocytes
Clone Cells
Genes
Immunoglobulin Subunits
T-Cell Antigen Receptor
Glycosylation

ASJC Scopus subject areas

  • General

Cite this

Saito, H., Kranz, D. M., Takagaki, Y., Hayday, A. C., Eisen, H. N., & Tonegawa, S. (1984). A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature, 312(5989), 36-40. https://doi.org/10.1038/312036a0

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. / Saito, Haruo; Kranz, David M; Takagaki, Yohtaroh; Hayday, Adrian C.; Eisen, Herman N.; Tonegawa, Susumu.

In: Nature, Vol. 312, No. 5989, 01.12.1984, p. 36-40.

Research output: Contribution to journalArticle

Saito, H, Kranz, DM, Takagaki, Y, Hayday, AC, Eisen, HN & Tonegawa, S 1984, 'A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes', Nature, vol. 312, no. 5989, pp. 36-40. https://doi.org/10.1038/312036a0
Saito H, Kranz DM, Takagaki Y, Hayday AC, Eisen HN, Tonegawa S. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature. 1984 Dec 1;312(5989):36-40. https://doi.org/10.1038/312036a0
Saito, Haruo ; Kranz, David M ; Takagaki, Yohtaroh ; Hayday, Adrian C. ; Eisen, Herman N. ; Tonegawa, Susumu. / A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. In: Nature. 1984 ; Vol. 312, No. 5989. pp. 36-40.
@article{e515e02371ba494ebec1b7b0f97bfdd1,
title = "A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes",
abstract = "In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.",
author = "Haruo Saito and Kranz, {David M} and Yohtaroh Takagaki and Hayday, {Adrian C.} and Eisen, {Herman N.} and Susumu Tonegawa",
year = "1984",
month = "12",
day = "1",
doi = "10.1038/312036a0",
language = "English (US)",
volume = "312",
pages = "36--40",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5989",

}

TY - JOUR

T1 - A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

AU - Saito, Haruo

AU - Kranz, David M

AU - Takagaki, Yohtaroh

AU - Hayday, Adrian C.

AU - Eisen, Herman N.

AU - Tonegawa, Susumu

PY - 1984/12/1

Y1 - 1984/12/1

N2 - In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.

AB - In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.

UR - http://www.scopus.com/inward/record.url?scp=0021129717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021129717&partnerID=8YFLogxK

U2 - 10.1038/312036a0

DO - 10.1038/312036a0

M3 - Article

C2 - 6208487

AN - SCOPUS:0021129717

VL - 312

SP - 36

EP - 40

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5989

ER -