A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase

S. G. Sligar, I. C. Gunsalus

Research output: Contribution to journalArticlepeer-review

Abstract

Regulation of biological phenomena occurs in all types of systems, being manifested in many different reactions types, from allosteric behavior in proteins, through modulation in energy and information transfer, to the control of growth and differentiation in cells, organelles, and organisms. In this communication, a modulation in oxidation/reduction potential via ligation of substrate and protein components in the camphor 5 exo monoxygenase system is described in terms of a four state system using as fundamental parameters the transition free energies between equilibrium states. This approach provides a concise description of the data and is useful for describing many aspects of regulatory phenomena.

Original languageEnglish (US)
Pages (from-to)1078-1082
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number4
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • General

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