TY - JOUR
T1 - A thermodynamic model of regulation
T2 - modulation of redox equilibria in camphor monoxygenase
AU - Sligar, S. G.
AU - Gunsalus, I. C.
PY - 1976
Y1 - 1976
N2 - Regulation of biological phenomena occurs in all types of systems, being manifested in many different reactions types, from allosteric behavior in proteins, through modulation in energy and information transfer, to the control of growth and differentiation in cells, organelles, and organisms. In this communication, a modulation in oxidation/reduction potential via ligation of substrate and protein components in the camphor 5 exo monoxygenase system is described in terms of a four state system using as fundamental parameters the transition free energies between equilibrium states. This approach provides a concise description of the data and is useful for describing many aspects of regulatory phenomena.
AB - Regulation of biological phenomena occurs in all types of systems, being manifested in many different reactions types, from allosteric behavior in proteins, through modulation in energy and information transfer, to the control of growth and differentiation in cells, organelles, and organisms. In this communication, a modulation in oxidation/reduction potential via ligation of substrate and protein components in the camphor 5 exo monoxygenase system is described in terms of a four state system using as fundamental parameters the transition free energies between equilibrium states. This approach provides a concise description of the data and is useful for describing many aspects of regulatory phenomena.
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U2 - 10.1073/pnas.73.4.1078
DO - 10.1073/pnas.73.4.1078
M3 - Article
C2 - 1063390
AN - SCOPUS:0001127948
SN - 0027-8424
VL - 73
SP - 1078
EP - 1082
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -