A systematic review of the factors influencing microbial colonization of the preterm infant gut

Miriam Aguilar-Lopez; Andrew M. Dinsmoor; Thao T.B. Ho; Sharon M. Donovan

doi:10.1080/19490976.2021.1884514

A systematic review of the factors influencing microbial colonization of the preterm infant gut

Miriam Aguilar-Lopez, Andrew M. Dinsmoor, Thao T.B. Ho, Sharon M. Donovan

Research output: Contribution to journal › Review article › peer-review

Abstract

Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.

Original language	English (US)
Pages (from-to)	1-33
Number of pages	33
Journal	Gut Microbes
Volume	13
Issue number	1
DOIs	https://doi.org/10.1080/19490976.2021.1884514
State	Published - 2021

Keywords

Preterm infant
antibiotics
dysbiosis
gut colonization
gut microbiota
human milk
mode of delivery

ASJC Scopus subject areas

Microbiology
Gastroenterology
Microbiology (medical)
Infectious Diseases

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10.1080/19490976.2021.1884514

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title = "A systematic review of the factors influencing microbial colonization of the preterm infant gut",

abstract = "Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.",

keywords = "Preterm infant, antibiotics, dysbiosis, gut colonization, gut microbiota, human milk, mode of delivery",

author = "Miriam Aguilar-Lopez and Dinsmoor, {Andrew M.} and Ho, {Thao T.B.} and Donovan, {Sharon M.}",

note = "Funding Information: This project was funded by Carle-Illinois seed grant to SMD and TH. MAL is supported by a fellowship from Consejo Nacional de Ciencia y Tecnolog{\'i}a. AMD is supported by a Jonathan Baldwin Turner fellowship from the College of Agricultural, Consumer and Environmental Sciences at the University of Illinois. Publisher Copyright: {\textcopyright} 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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doi = "10.1080/19490976.2021.1884514",

language = "English (US)",

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AU - Aguilar-Lopez, Miriam

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AU - Ho, Thao T.B.

AU - Donovan, Sharon M.

N1 - Funding Information: This project was funded by Carle-Illinois seed grant to SMD and TH. MAL is supported by a fellowship from Consejo Nacional de Ciencia y Tecnología. AMD is supported by a Jonathan Baldwin Turner fellowship from the College of Agricultural, Consumer and Environmental Sciences at the University of Illinois. Publisher Copyright: © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2021

Y1 - 2021

N2 - Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.

AB - Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Future studies with rich metadata are needed to further explore the impact of the PT exposome on the development of the microbiota in this high-risk population.

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KW - gut colonization

KW - gut microbiota

KW - human milk

KW - mode of delivery

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A systematic review of the factors influencing microbial colonization of the preterm infant gut

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Keywords

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