Abstract
We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast.
Original language | English (US) |
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Pages (from-to) | 4998-5000 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 47 |
Issue number | 17 |
DOIs | |
State | Published - May 7 2011 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry