A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity

Benjamin R. Trible; Luca N. Popescu; Nicholas Monday; Jay G. Calvert; Raymond R.R. Rowland

doi:10.1128/JVI.03287-14

A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity

Benjamin R. Trible, Luca N. Popescu, Nicholas Monday, Jay G. Calvert, Raymond R.R. Rowland

Research output: Contribution to journal › Article › peer-review

Abstract

Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein provided escape from broad neutralization without affecting homologous neutralizing activity. The role of the Tyr-10 deletion was confirmed through an infectious clone with a Tyr-10 deletion. The results demonstrate differences in the properties and specificities of VN responses elicited during PRRSV infection.

Original language	English (US)
Pages (from-to)	6515-6520
Number of pages	6
Journal	Journal of virology
Volume	89
Issue number	12
DOIs	https://doi.org/10.1128/JVI.03287-14
State	Published - 2015
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.03287-14

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A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity. / Trible, Benjamin R.; Popescu, Luca N.; Monday, Nicholas et al.

In: Journal of virology, Vol. 89, No. 12, 2015, p. 6515-6520.

Research output: Contribution to journal › Article › peer-review

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AB - Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein provided escape from broad neutralization without affecting homologous neutralizing activity. The role of the Tyr-10 deletion was confirmed through an infectious clone with a Tyr-10 deletion. The results demonstrate differences in the properties and specificities of VN responses elicited during PRRSV infection.

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A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity

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