A simultaneous saccharification and fermentation model for dynamic growth environments

Ganti S. Murthy, David B. Johnston, Kent D. Rausch, M. E. Tumbleson, Vijay Singh

Research output: Contribution to journalArticlepeer-review


Many mathematical models by researchers have been formulated for Saccharomyces cerevisiae which is the common yeast strain used in modern distilleries. A cybernetic model that can account for varying concentrations of glucose, ethanol and organic acids on yeast cell growth dynamics does not exist. A cybernetic model, consisting of 4 reactions and 11 metabolites simulating yeast metabolism, was developed. The effects of variables such as temperature, pH, organic acids, initial inoculum levels and initial glucose concentration were incorporated into the model. Further, substrate and product inhibitions were included. The model simulations over a range of variables agreed with hypothesized trends and to observations from other researchers. Simulations converged to expected results and exhibited continuity in predictions for all ranges of variables simulated. The cybernetic model did not exhibit instability under any conditions simulated.

Original languageEnglish (US)
Pages (from-to)519-534
Number of pages16
JournalBioprocess and Biosystems Engineering
Issue number4
StatePublished - May 2012


  • Convergence
  • Cybernetic model
  • Environmental effects
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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