A simulation of voltage clamp experiments on frog atrial trabeculae

E. Jakobsson, J. A. Connor, L. Barr

Research output: Contribution to journalArticlepeer-review

Abstract

The authors carried out a computer simulation of the behavior of a short length of frog atrial trabecula in a test node of a double sucrose gap. The preparation was represented by a distributed coaxial core model, the inner elements of which were in series with an appreciable extracellular resistance. The outer annulus of cells was assumed to be in series with negligible extracellular resistance. Values for membrane resistance and capacitance, extracellular resistance, and other parameters were chosen to match the passive electrical characteristics of the preparation. The analog network assumes Hodgkin Huxley type membrane parameters for the lumped cell membrane elements while the passive interconnecting elements are taken to be simple resistances. The ranges of the analog parameters necessary for adequate space clamp behavior are discussed. The model presented here was designed to account for the following: the wide test node which can be tolerated before electrical instability occurs, the slow charging of membrane capacitance, and the anomalously high observed reversal potential for the sodium transient.

Original languageEnglish (US)
Pages (from-to)No. 1012
JournalFederation Proceedings
Volume33
Issue number5 II
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Medicine(all)

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