TY - JOUR
T1 - A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs
AU - Hatoum-Aslan, Asma
AU - Samai, Poulami
AU - Maniv, Inbal
AU - Jiang, Wenyan
AU - Marraffini, Luciano A.
PY - 2013/9/27
Y1 - 2013/9/27
N2 - Background: CRISPR immune systems protect prokaryotes from their viruses using small interfering RNAs (crRNAs), which require maturation events during their biogenesis. Results: In Staphylococcus epidermidis, crRNAs undergo maturation in a Cas10-Csm ribonucleoprotein complex; Csm3 modulates the extent of maturation. Conclusion: Csm3 acts as a ruler for crRNAs. Significance: Investigating CRISPR immunity is important to understand prokaryotic ecology and to develop biotechnological applications.
AB - Background: CRISPR immune systems protect prokaryotes from their viruses using small interfering RNAs (crRNAs), which require maturation events during their biogenesis. Results: In Staphylococcus epidermidis, crRNAs undergo maturation in a Cas10-Csm ribonucleoprotein complex; Csm3 modulates the extent of maturation. Conclusion: Csm3 acts as a ruler for crRNAs. Significance: Investigating CRISPR immunity is important to understand prokaryotic ecology and to develop biotechnological applications.
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U2 - 10.1074/jbc.M113.499244
DO - 10.1074/jbc.M113.499244
M3 - Article
C2 - 23935102
AN - SCOPUS:84884765703
SN - 0021-9258
VL - 288
SP - 27888
EP - 27897
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 39
ER -