A rule-based framework for gene regulation pathways discovery

B. Wilczyński, T. Hvidsten, A. Kryshtafovych, L. Stubbs, J. Komorowski, K. Fidelis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a novel approach for rule discovery in the area of gene regulation. The method is based on supervised machine learning and is designed to reveal relationships between transcription factors and gene expression. As a representation of the gene regulatory circuit we have chosen a special form of the IF-THEN rules associating predefined features, taken here as a generalized idea of transcription factor binding sites in gene regulatory regions, with the corresponding gene expression profiles.

Original languageEnglish (US)
Title of host publicationProceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages435-436
Number of pages2
ISBN (Electronic)0769520006, 9780769520001
DOIs
StatePublished - Jan 1 2003
Externally publishedYes
Event2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003 - Stanford, United States
Duration: Aug 11 2003Aug 14 2003

Publication series

NameProceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003

Other

Other2nd International IEEE Computer Society Computational Systems Bioinformatics Conference, CSB 2003
CountryUnited States
CityStanford
Period8/11/038/14/03

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

Wilczyński, B., Hvidsten, T., Kryshtafovych, A., Stubbs, L., Komorowski, J., & Fidelis, K. (2003). A rule-based framework for gene regulation pathways discovery. In Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003 (pp. 435-436). [1227361] (Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CSB.2003.1227361