@inproceedings{4f26580bd3d7454f9a1c63bfdaf626d8,
title = "A quantitative ultrasound-based method and device for reliably guiding pathologists to metastatic regions of dissected lymph nodes",
abstract = "Our group is developing a method based on 3D high-frequency ultrasound (HFU) and 3D quantitative ultrasound (QUS) to help pathologists detect micrometastases in freshly-excised lymph nodes of patients with histologically-proven primary cancer. From a signal and image processing perspective, we report on our efforts to acquire and classify lymph-node tissue based on 3D QUS parameter estimates. We evaluated classifier performance against gold-standard histology. Using our database of 134 abdominal cancer-free nodes and 26 fully cancerous abdominal nodes, a conservative threshold gave a sensitivity and specificity of 99.3% and 73.1%, respectively. We also constructed a 3D cancer-likelihood map of a partially metastatic lymph node and compared that map with histology. This representation potentially can be useful for guiding pathologists to suspicious regions requiring histological evaluation.",
keywords = "high-frequency ultrasound, histology, lymph nodes, metastatic cancer, quantitative ultrasound, registration, segmentation",
author = "Alain Coron and Jonathan Mamou and Emi Saegusa-Beecroft and Oelze, {Michael L.} and Tadashi Yamaguchi and Masaki Hata and Junji MacHi and Eugene Yanagihara and Pascal Laugier and Feleppa, {Ernest J.}",
year = "2012",
doi = "10.1109/ISBI.2012.6235742",
language = "English (US)",
isbn = "9781457718588",
series = "Proceedings - International Symposium on Biomedical Imaging",
pages = "1064--1067",
booktitle = "2012 9th IEEE International Symposium on Biomedical Imaging",
note = "2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 ; Conference date: 02-05-2012 Through 05-05-2012",
}