A quantitative ultrasound-based method and device for reliably guiding pathologists to metastatic regions of dissected lymph nodes

Alain Coron, Jonathan Mamou, Emi Saegusa-Beecroft, Michael L. Oelze, Tadashi Yamaguchi, Masaki Hata, Junji MacHi, Eugene Yanagihara, Pascal Laugier, Ernest J. Feleppa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our group is developing a method based on 3D high-frequency ultrasound (HFU) and 3D quantitative ultrasound (QUS) to help pathologists detect micrometastases in freshly-excised lymph nodes of patients with histologically-proven primary cancer. From a signal and image processing perspective, we report on our efforts to acquire and classify lymph-node tissue based on 3D QUS parameter estimates. We evaluated classifier performance against gold-standard histology. Using our database of 134 abdominal cancer-free nodes and 26 fully cancerous abdominal nodes, a conservative threshold gave a sensitivity and specificity of 99.3% and 73.1%, respectively. We also constructed a 3D cancer-likelihood map of a partially metastatic lymph node and compared that map with histology. This representation potentially can be useful for guiding pathologists to suspicious regions requiring histological evaluation.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages1064-1067
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
Country/TerritorySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • high-frequency ultrasound
  • histology
  • lymph nodes
  • metastatic cancer
  • quantitative ultrasound
  • registration
  • segmentation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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