TY - JOUR
T1 - A prospective study of the effects of female and male marijuana use on in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) outcomes
AU - Klonoff-Cohen, Hillary
AU - Natarajan, Loki
AU - Victoria Chen, Rosa
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Objective: This study was undertaken to examine whether marijuana use affects in vitro fertilization and gamete intrafallopian transfer (IVF/GIFT). Study design: Prospective study of 221 IVF/GIFT couples. Results: Amount of lifetime heavy marijuana use adversely affected IVF/GIFT. Women smoking more than 90 times in their lifetime had 27% fewer oocytes retrieved (P = .03) and 1 fewer embryo transferred (P < .05). Women smoking marijuana more than 10 times in their lifetime had infants 17% (P = .01) smaller at birth. If men smoked marijuana 11 to 90 times in their lifetime, there was a 15% decrease in infant birth weight (P = .03); if this increased to more than 90 times, there was a 23% decrease (P = .01). Timing also played a role. Women smoking marijuana 1 year before IVF/GIFT had 25% fewer oocytes retrieved (P = .03), whereas couples had 28% (P = .04) fewer oocytes fertilized. Women and men who smoked in the past 15 years, had 12%(P = .04) and 16% (P = .03) smaller infants, respectively. Conclusion: Both timing and amount of marijuana use negatively affected IVF/GIFT.
AB - Objective: This study was undertaken to examine whether marijuana use affects in vitro fertilization and gamete intrafallopian transfer (IVF/GIFT). Study design: Prospective study of 221 IVF/GIFT couples. Results: Amount of lifetime heavy marijuana use adversely affected IVF/GIFT. Women smoking more than 90 times in their lifetime had 27% fewer oocytes retrieved (P = .03) and 1 fewer embryo transferred (P < .05). Women smoking marijuana more than 10 times in their lifetime had infants 17% (P = .01) smaller at birth. If men smoked marijuana 11 to 90 times in their lifetime, there was a 15% decrease in infant birth weight (P = .03); if this increased to more than 90 times, there was a 23% decrease (P = .01). Timing also played a role. Women smoking marijuana 1 year before IVF/GIFT had 25% fewer oocytes retrieved (P = .03), whereas couples had 28% (P = .04) fewer oocytes fertilized. Women and men who smoked in the past 15 years, had 12%(P = .04) and 16% (P = .03) smaller infants, respectively. Conclusion: Both timing and amount of marijuana use negatively affected IVF/GIFT.
KW - Gamete intrafallopian transfer
KW - In vitro fertilization
KW - Live birth delivery
KW - Marijuana
KW - Pregnancy
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U2 - 10.1016/j.ajog.2005.08.020
DO - 10.1016/j.ajog.2005.08.020
M3 - Article
C2 - 16458631
AN - SCOPUS:31844435563
VL - 194
SP - 369
EP - 376
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -