A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Keyphrases

• Triplet 100%
• CUG Repeats 100%
• Myotonic Dystrophy 100%
• Potent Inhibitor 100%
• Drosophila Model 100%
• Phenotypic Improvement 100%
• Protein Sequestration 100%
• Small Molecules 33%
• Disease Phenotype 33%
• HeLa Cells 33%
• Sequester 33%
• Alternative Splicing 33%
• Model Cell 33%
• Crawling 33%
• Targeted Agents 33%
• Maximum Tolerated Dose 33%
• Muscular Dystrophy 33%
• Cell Uptake 33%
• Most Common Form 33%
• Pre-mRNA 33%
• Insulin Receptor 33%
• MBNL1 33%
• Inhibition Constant 33%
• Deregulation 33%
• Adult-onset 33%
• DMPK Gene 33%
• Nuclear Foci 33%
• CTG Repeat Expansion 33%
• External Eye 33%
• Splicing Defect 33%
• Eye Degeneration 33%

Biochemistry, Genetics and Molecular Biology

• Fruit Fly Model 100%
• RNA 50%
• Small Molecule 50%
• Mouse 50%
• Alternative Splicing 50%
• Precursor mRNA 50%
• Insulin Receptor 50%
• MBNL1 50%
• Maximum Tolerated Dose 50%
• Splicing Defect 50%

Neuroscience

• Myotonic Dystrophy 100%
• Alternative Splicing 33%
• Precursor mRNA 33%
• Muscular Dystrophy 33%
• Insulin Receptor 33%
• Splicing Defect 33%