A possible cumulative shear mechanism for tissue damage initiation in SWL

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In shock-wave lithotripsy, inertial cavitation is observed in kidney tissue after hundreds of shocks are delivered, which seems to correspond with the onset of wide-spread injury. However, it is unclear what initiates the process. It is possible, and has been suggested before, that hemorrhage is a prelude to cavitation damage. We investigate the possibility that the net shear of multiple shocks can accumulate to cause this initial hemorrhage. A mathematical model is used to show that the larger interstitial volume fraction in the medulla toward the papilla tip would make it particularly sensitive there to this mechanism. This is consistent with observations.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
Pages356-359
Number of pages4
StatePublished - May 11 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
Volume900
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Keywords

  • Shock-wave lithotripsy
  • Tissue damage

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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