A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

Roger M. Pallares, Say Li Kong, Tan Hui Ru, Nguyên T.K. Thanh, Yi Lu, Xiaodi Su

Research output: Contribution to journalArticlepeer-review

Abstract

A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod aggregation. This assay method can adjust the dynamic range by controlling the concentration of nanoparticles in solution.

Original languageEnglish (US)
Pages (from-to)14524-14527
Number of pages4
JournalChemical Communications
Volume51
Issue number77
DOIs
StatePublished - Aug 6 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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