TY - JOUR
T1 - A Pilot Study to Evaluate the Impact of the HIV Infant Tracking System (HITSystem 2.0) on Priority Prevention of Mother-to-Child Transmission (PMTCT) Outcomes
AU - Finocchario-Kessler, Sarah
AU - Brown, Melinda
AU - Maloba, May
AU - Nazir, Niaman
AU - Wexler, Catherine
AU - Goggin, Kathy
AU - Dariotis, Jacinda K.
AU - Mabachi, Natabhona
AU - Lagat, Silas
AU - Koech, Sharon
AU - Gautney, Brad
N1 - Funding Information:
All authors’ effort on this project was supported by grant R34MH107337 from the National Institute of Mental Health and the University of Kansas School of Medicine Bridging Grant. The National institutes of Mental Health played no role in the design of the study, data collection, the writing of the manuscript, or the decision to submit for publication. We would like to thank the participants of this study and healthcare providers at the study hospitals. We acknowledge the members of the Kenya HITSystem Study Team: Emmy Kavaya, Philomena Chepchirchir, and Hellen Murei. We also acknowledge the critical role of our government partners at the Kenya National AIDS and STI Control Program (NASCOP). We thank the Director, KEMRI for permission to publish this manuscript. We thank the HITSystem software developers at OnTarget LLC, Terry Oehrke and Matt Coleman for their commitment and contributions. We are grateful for the significant contributions made by Dr. Vince Staggs in refining and strengthening the statistical analysis plan.
Funding Information:
All authors’ effort on this project was supported by grant R34MH107337 from the National Institute of Mental Health and the University of Kansas School of Medicine Bridging Grant. The National institutes of Mental Health played no role in the design of the study, data collection, the writing of the manuscript, or the decision to submit for publication. We would like to thank the participants of this study and healthcare providers at the study hospitals. We acknowledge the members of the Kenya HITSystem Study Team: Emmy Kavaya, Philomena Chepchirchir, and Hellen Murei. We also acknowledge the critical role of our government partners at the Kenya National AIDS and STI Control Program (NASCOP). We thank the Director, KEMRI for permission to publish this manuscript. We thank the HITSystem software developers at OnTarget LLC, Terry Oehrke and Matt Coleman for their commitment and contributions. We are grateful for the significant contributions made by Dr. Vince Staggs in refining and strengthening the statistical analysis plan.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
PY - 2021/8
Y1 - 2021/8
N2 - We assessed the preliminary impact of the adapted HIV Infant Tracking System (HITSystem v2.0) intervention on prevention of mother-to-child transmission (PMTCT) outcomes using a matched cluster randomized design in two Kenyan government hospitals. Between November 2017 and June 2019, n = 157 pregnant women with HIV were enrolled and followed from their first PMTCT appointment until 12-weeks postpartum. Data from 135 women were analyzed (HITSystem 2.0: n = 53, standard of care (SOC): n = 82), excluding eight deaths, eight pregnancy losses, and six transfers/moves. The primary outcome, complete PMTCT retention, is an aggregate measure of attendance at all scheduled antenatal appointments, hospital-based delivery, and infant HIV-testing before 7-weeks postnatal. HITSystem 2.0 participants were more likely to receive complete PMTCT services compared to SOC (56.6% vs. 17.1% p < 0.001). In multivariate modeling, HITSystem 2.0 was the strongest predictor of complete PMTCT retention (aOR 5.7, [1.2–90.8], p = 0.032). SOC participants had 1.91 increased hazard rate of PMTCT disengagement; (aHR 6.8, [2.2–21.1]; p < 0.001).
AB - We assessed the preliminary impact of the adapted HIV Infant Tracking System (HITSystem v2.0) intervention on prevention of mother-to-child transmission (PMTCT) outcomes using a matched cluster randomized design in two Kenyan government hospitals. Between November 2017 and June 2019, n = 157 pregnant women with HIV were enrolled and followed from their first PMTCT appointment until 12-weeks postpartum. Data from 135 women were analyzed (HITSystem 2.0: n = 53, standard of care (SOC): n = 82), excluding eight deaths, eight pregnancy losses, and six transfers/moves. The primary outcome, complete PMTCT retention, is an aggregate measure of attendance at all scheduled antenatal appointments, hospital-based delivery, and infant HIV-testing before 7-weeks postnatal. HITSystem 2.0 participants were more likely to receive complete PMTCT services compared to SOC (56.6% vs. 17.1% p < 0.001). In multivariate modeling, HITSystem 2.0 was the strongest predictor of complete PMTCT retention (aOR 5.7, [1.2–90.8], p = 0.032). SOC participants had 1.91 increased hazard rate of PMTCT disengagement; (aHR 6.8, [2.2–21.1]; p < 0.001).
KW - ART adherence
KW - Appointment attendance
KW - Complete PMTCT retention
KW - EHealth
KW - Facility deliveries
KW - HIV
KW - Kenya
KW - MHealth
KW - PMTCT
KW - Pregnancy
KW - Retention
KW - Women
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UR - http://www.scopus.com/inward/citedby.url?scp=85102490115&partnerID=8YFLogxK
U2 - 10.1007/s10461-021-03204-0
DO - 10.1007/s10461-021-03204-0
M3 - Article
C2 - 33709212
AN - SCOPUS:85102490115
SN - 1090-7165
VL - 25
SP - 2419
EP - 2429
JO - AIDS and Behavior
JF - AIDS and Behavior
IS - 8
ER -