A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis

Efa A. Llewellyn, Jeffrey M. Todd, Leslie C. Sharkey, Aaron Rendahl

Research output: Contribution to journalArticlepeer-review


Objective: To characterize platelet indices at time of diagnosis of septic peritonitis in dogs and to assess the relationship between platelet parameter data and survival to discharge in dogs treated surgically. Design: Retrospective, observational, descriptive pilot study from 2009 to 2014. Setting: University teaching hospital. Animals: Forty-eight dogs diagnosed with septic peritonitis were included in this study. Thirty-six dogs had surgical source control. Blood samples from 46 healthy control dogs were used for reference interval (RI) generation. Interventions: None. Measurements and Main Results: Dogs with septic peritonitis had significantly increased mean values for mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) with increased proportions of dogs having values above the RI compared to healthy dogs. A significantly increased proportion of dogs with septic peritonitis had platelet counts above (12.5%) and below (8.3%) the RI, with no significant difference in mean platelet count compared to healthy dogs. No significant differences in the mean platelet count, MPV, PCT, or PDW were found between survivors and nonsurvivors in dogs with surgical source control; however, dogs with MPV values above the RI had significantly increased mortality compared to dogs within the RI (P = 0.025). Values outside the RI for other platelet parameters were not associated with significant differences in mortality. Conclusions: Dogs with septic peritonitis have increased frequency of thrombocytosis and thrombocytopenia with increased MPV, PCT, and PDW. An increased MPV may be a useful indicator of increased risk of mortality in dogs treated surgically.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalJournal of Veterinary Emergency and Critical Care
Issue number5
StatePublished - Sep 1 2017


  • macroplatelets
  • mean platelet volume
  • platelet distribution width
  • plateletcrit
  • sepsis
  • systemic inflammatory response syndrome

ASJC Scopus subject areas

  • General Veterinary


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