The previously determined sequence of the murine T-cell γ gene and its transcription in cloned T lymphocytes suggests that the polypeptide encoded by this gene is generally present in cytotoxic T cells as a 33-kDa monomer in a disulfide-bonded dimer. The γ chain is also expected to be phosphorylated because a sequence in its cytoplasmic domain is homologous to an active site for serine phosphorylation in the regulatory subunit of cAMP-dependent protein kinase. We describe here a cytotoxic T-cell-associated phosphorylated protein, many of whose properties suggest that it may be the product of the T-cell γ gene. Its phosphorylation is greatly enhanced by interleukin 2 stimulation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Dec 1 1986|
ASJC Scopus subject areas