A phosphorylated, disulfide-linked membrane protein in murine cytotoxic T lymphocytes

J. Lieberman, C. R. Verret, D. M. Kranz, S. C. Hubbard, H. Saito, D. H. Raulet, S. Tonegawa, H. N. Eisen

Research output: Contribution to journalArticle

Abstract

The previously determined sequence of the murine T-cell γ gene and its transcription in cloned T lymphocytes suggests that the polypeptide encoded by this gene is generally present in cytotoxic T cells as a 33-kDa monomer in a disulfide-bonded dimer. The γ chain is also expected to be phosphorylated because a sequence in its cytoplasmic domain is homologous to an active site for serine phosphorylation in the regulatory subunit of cAMP-dependent protein kinase. We describe here a cytotoxic T-cell-associated phosphorylated protein, many of whose properties suggest that it may be the product of the T-cell γ gene. Its phosphorylation is greatly enhanced by interleukin 2 stimulation.

Original languageEnglish (US)
Pages (from-to)7870-7874
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number20
DOIs
StatePublished - Dec 1 1986
Externally publishedYes

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