A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model

Li Ma, Haiyan Gong, Haiyan Zhu, Qing Ji, Pei Su, Peng Liu, Shannan Cao, Jianfeng Yao, Linlin Jiang, Mingzhe Han, Xiaotong Ma, Dongsheng Xiong, Hongbo R. Luo, Fei Wang, Jiaxi Zhou, Yuanfu Xu

Research output: Contribution to journalArticle

Abstract

Background: Most commercial TNFα inhibitors are biomacromolecules. Results: A lead compound named C87 was identified using computer-aided drug design and could attenuate murine acute hepatitis. Conclusion: C87 was one of the first effective small-molecule inhibitors of TNFα identified to date. Significance: The study highlights the effectiveness of combining virtual screening with functional assays for developing novel small-molecule TNFα inhibitors.

Original languageEnglish (US)
Pages (from-to)12457-12466
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model'. Together they form a unique fingerprint.

  • Cite this

    Ma, L., Gong, H., Zhu, H., Ji, Q., Su, P., Liu, P., Cao, S., Yao, J., Jiang, L., Han, M., Ma, X., Xiong, D., Luo, H. R., Wang, F., Zhou, J., & Xu, Y. (2014). A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. Journal of Biological Chemistry, 289(18), 12457-12466. https://doi.org/10.1074/jbc.M113.521708