A novel indicator series for measuring pKa values in acetonitrile

Jennifer M. Heemstra, Jeffrey S. Moore

Research output: Contribution to journalArticle

Abstract

A series of substituted azobenzene dyes was found to span a range of 8 pKa units in acetonitrile. The UV absorption spectra of the dyes are responsive to protonation, changing in both absorption maximum and intensity. These characteristics make the dyes useful as indicators for the measurement of pKa values of neutral organic bases that absorb in the visible region of the spectrum.

Original languageEnglish (US)
Pages (from-to)7287-7292
Number of pages6
JournalTetrahedron
Volume60
Issue number34
DOIs
StatePublished - Aug 16 2004

Keywords

  • Azobenzene
  • Indicator
  • Organic base

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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