A new noninvasive imaging technique for cataract evaluation in the rhesus monkey.

Cheryl D. Dicar, Stephen Boppart, Donald A. Gagliano, Rodney Amnotte, Audrey B. Smith, Daniel X. Hammer, Ann B. Cox, Michael R. Hee, James Fujimoto, Eric Swanson, W. P. Roach

Research output: Contribution to journalConference article

Abstract

We present the first in vivo study using Optical Coherence Tomography (OCT)' as the imaging device for lenticular cataracts in the geriatric rhesus monkey. OCT is a non-invasive imaging technique that produces a two dimensional cross sectional image of intraocular tissue similar to ultrasound B scan. In OCT the images are formed by measuring optical reflections from the tissue. Eighteen geriatric subjects with documented lenticular opacities and one control subject were imaged. The OCT images produced are compared to current and previous clinical cataract grading exams and slit-lamp photography. Histopathology was collected on one subject and is compared to the OCT image. OCT provides information on nuclear, cortical and subcapsular opacities. The image information is presented based on a color coded computer generated log reflective scale. The log reflective scale is converted to a qualitative grading system. Although movement and shadow artifact can occur, these are readily identifiable and can be differentiated from underlying lenticular abnormalities. OCT has great potential to assist in further characterization of cataracts.

Original languageEnglish (US)
Pages (from-to)636-643
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2395
DOIs
StatePublished - May 12 1995
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems V 1995 - San Jose, United States
Duration: Feb 1 1995Feb 28 1995

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Dicar, C. D., Boppart, S., Gagliano, D. A., Amnotte, R., Smith, A. B., Hammer, D. X., Cox, A. B., Hee, M. R., Fujimoto, J., Swanson, E., & Roach, W. P. (1995). A new noninvasive imaging technique for cataract evaluation in the rhesus monkey. Proceedings of SPIE - The International Society for Optical Engineering, 2395, 636-643. https://doi.org/10.1117/12.209062