A new non-viral conjugate as a promising carrier system for DNA delivery

Wu Yundong, Liu Chengbin, Zhao Xiangyun, Xiang Jiannan, Nie Shuming

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new non-viral conjugate, chitosan-g-PEI-g-PEG-OH polymer, was synthesized using grafting reaction with chitosan, polyethylenimine and polyethylene glycol for constructing aniphiphilic grafting copolymers. The conjugates were characterized by IR and 1HNMR, and can self-assembled to form micelle-like nanoparticles in the aqueous media at the PH value of 5. The size of the nanoparticles was in the range of 30-50 nm. The hydrotropic polymer micelles provide an alternative approach for DNA delivery.

Original languageEnglish (US)
Title of host publication2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
Pages1974-1977
Number of pages4
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
Event2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 - Beijing, China
Duration: May 23 2007May 27 2007

Publication series

Name2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007

Other

Other2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007
CountryChina
CityBeijing
Period5/23/075/27/07

Keywords

  • Chitosan
  • Non-viral carrier
  • Polyethylene glycol
  • Polyethylenimine

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

Fingerprint Dive into the research topics of 'A new non-viral conjugate as a promising carrier system for DNA delivery'. Together they form a unique fingerprint.

  • Cite this

    Yundong, W., Chengbin, L., Xiangyun, Z., Jiannan, X., & Shuming, N. (2007). A new non-viral conjugate as a promising carrier system for DNA delivery. In 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 (pp. 1974-1977). [4382093] (2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007). https://doi.org/10.1109/ICCME.2007.4382093