Abstract
A new non-viral conjugate, chitosan-g-PEI-g-PEG-OH polymer, was synthesized using grafting reaction with chitosan, polyethylenimine and polyethylene glycol for constructing aniphiphilic grafting copolymers. The conjugates were characterized by IR and 1HNMR, and can self-assembled to form micelle-like nanoparticles in the aqueous media at the PH value of 5. The size of the nanoparticles was in the range of 30-50 nm. The hydrotropic polymer micelles provide an alternative approach for DNA delivery.
Original language | English (US) |
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Title of host publication | 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 |
Pages | 1974-1977 |
Number of pages | 4 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
Event | 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 - Beijing, China Duration: May 23 2007 → May 27 2007 |
Publication series
Name | 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 |
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Other
Other | 2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007 |
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Country/Territory | China |
City | Beijing |
Period | 5/23/07 → 5/27/07 |
Keywords
- Chitosan
- Non-viral carrier
- Polyethylene glycol
- Polyethylenimine
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine(all)