A new method for SPECT quantification of targeted radiotracers uptake in the myocardium

Shimin Li, Lawrence W. Dobrucki, Albert J. Sinusas, Yi Hwa Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a new method for absolute quantification of targeted radiotracers uptake in the myocardium using hybrid SPECT/CT and an external reference point source. A segmentation algorithm based on the level set was developed to determine the endocardial edges from CT, which were subsequently applied to the physically co-registered SPECT. A 3-D Gaussian fitting method was applied for quantification of the external point source. The total targeted radiotracer activity in the myocardium was normalized to that in the point source to calculate the absolute uptake of targeted radiotracer in the myocardium. Preliminary validation was performed in rats with ischemia-induced angiogenesis. The quantified in vivo radiotracer uptake was compared to the postmortem tissue radioactive well-counting of the myocardium. Our methods worked well for identification of the endocardial edges. Quantification of the focal uptake was consistent with the well-counting data. Our methods may have the potential of providing precise absolute quantification of targeted radiotracer uptake in the myocardium.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
PublisherSpringer-Verlag Berlin Heidelberg
Pages684-691
Number of pages8
ISBN (Print)3540293264, 9783540293262
DOIs
StatePublished - 2005
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
Duration: Oct 26 2005Oct 29 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3750 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
CountryUnited States
CityPalm Springs, CA
Period10/26/0510/29/05

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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    Li, S., Dobrucki, L. W., Sinusas, A. J., & Liu, Y. H. (2005). A new method for SPECT quantification of targeted radiotracers uptake in the myocardium. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings (pp. 684-691). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 3750 LNCS). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/11566489_84