A new coarse-to-fine framework for 3D brain MR image registration

Terrence Chen, Thomas S. Huang, Wotao Yin, Xiang Sean Zhou

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Registration, that is, the alignment of multiple images, has been one of the most challenging problems in the field of computer vision. It also serves as an important role in biomedical image analysis and its applications. Although various methods have been proposed for solving different kinds of registration problems in computer vision, the results are still far from ideal when it comes to real world biomedical image applications. For instance, in order to register 3D brain MR images, current state of the art registration methods use a multi-resolution coarse-to-fine algorithm, which typically involves starting with low resolution images and working progressively through to higher resolutions, with the aim to avoid the local maximum "traps". However, these methods do not always successfully avoid the local maximum. Consequently, various rather sophisticated optimization methods are developed to attack this problem. In this paper, we propose a novel viewpoint on the coarse-to-fine registration, in which coarse and fine images ate distinguished by different scales of the objects instead of different resolutions of the images. Based on this new perspective, we develop a new image registration framework by combining the multi-resolution method with novel multi-scale algorithm, which could achieve higher accuracy and robustness on 3D brain MR images. We believe this work has great contribution to biomedical image analysis and related applications.

Original languageEnglish (US)
Title of host publicationComputer Vision for Biomedical Image Applications - First International Workshop, CVBIA 2005, Proceedings
Number of pages11
ISBN (Print)3540294112, 9783540294115
StatePublished - 2005
Externally publishedYes
Event1st International Workshop on Computer Vision for Biomedical Image Applications, CVBIA 2005 - Beijing, China
Duration: Oct 21 2005Oct 21 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3765 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other1st International Workshop on Computer Vision for Biomedical Image Applications, CVBIA 2005

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)


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