A new class of arylamine oxygenases: Evidence that p-aminobenzoate N-oxygenase (AurF) is a di-iron enzyme and further mechanistic studies

Michael Simurdiak, Jungkul Lee, Huimin Zhao

Research output: Contribution to journalArticlepeer-review

Abstract

Alternative route. The p-aminobenzoate N-oxygenase (AurF) from the aureothin biosynthetic pathway in Streptomyces thioluteus is a novel di-iron enzyme. Rather than through the previously proposed mechanism, AurF in fact catalyzes the conversion of substrate p-aminobenzoate to p-nitrobenzoate through at least three consecutive reactions: two monooxygenation steps (a and c) and one dehydrogenation step (b).

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalChemBioChem
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2006

Keywords

  • Amines
  • Enzyme catalysis
  • Oxygenation
  • Reaction mechanisms

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

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