@inproceedings{14b70e15cdf14cd2a407f77b0ff6820c,
title = "A multiplexed microfluidic platform utilizing optimized normally closed valves for investigating microbial gene expression",
abstract = "This paper reports the development of a microfluidic platform that utilizes arrays of normally closed (NC) microvalves, and its application in quantitative biological measurements, including microbial gene expression and stimulus-driven responses in living cells. The dimensions of the NC valves used in this platform were first optimized to actuate reliably at low negative pressures (-1 to -3 psig). The platform was then employed to investigate (i) inducible gene expression in Escherichia coli and (ii) the effect of an antibiotic (ampicillin) on cell growth and death.",
keywords = "Antibiotics, Green fluorescent protein (GFP), Normally closed microvalve, Soft lithography",
author = "Ritika Mohan and Arnab Mukherjee and Desai, {Amit V.} and Jaebum Lee and Schroeder, {Charles M.} and Kenis, {Paul J.A.}",
year = "2011",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "1014--1016",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}