A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Sarmi Sri; Adam Greenstein; Alessandra Granata; Alex Collcutt; Angela C.C. Jochems; Barry W. McColl; Blanca Díaz Castro; Caleb Webber; Carmen Arteaga Reyes; Catherine Hall; Catherine B. Lawrence; Cheryl Hawkes; Chrysia Maria Pegasiou-Davies; Claire Gibson; Colin L. Crawford; Colin Smith; Denis Vivien; Fiona H. McLean; Frances Wiseman; Gaia Brezzo; Giovanna Lalli; Harry A.T. Pritchard; Hugh S. Markus; Isabel Bravo-Ferrer; Jade Taylor; James Leiper; Jason Berwick; Jian Gan; John Gallacher; Jonathan Moss; Jozien Goense; Letitia McMullan; Lorraine Work; Lowri Evans; Michael S. Stringer; M. L.J. Ashford; Mohamed Abulfadl; Nina Conlon; Paresh Malhotra; Philip Bath; Rebecca Canter; Rosalind Brown; Selvi Ince; Silvia Anderle; Simon Young; Sophie Quick; Stefan Szymkowiak; Steve Hill; Stuart Allan; Tao Wang; Terry Quinn; Tessa Procter; Tracy D. Farr; Xiangjun Zhao; Zhiyuan Yang; Atticus H. Hainsworth; Joanna M. Wardlaw

doi:10.1016/j.cccb.2023.100189

A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C.C. Jochems, Barry W. McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B. Lawrence, Cheryl Hawkes, Chrysia Maria Pegasiou-Davies, Claire Gibson, Colin L. Crawford, Colin Smith, Denis Vivien, Fiona H. McLean, Frances Wiseman, Gaia BrezzoGiovanna Lalli, Harry A.T. Pritchard, Hugh S. Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S. Stringer, M. L.J. Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D. Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H. Hainsworth, Joanna M. Wardlaw

Research output: Contribution to journal › Review article › peer-review

Abstract

Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

Original language	English (US)
Article number	100189
Journal	Cerebral Circulation - Cognition and Behavior
Volume	5
DOIs	https://doi.org/10.1016/j.cccb.2023.100189
State	Published - Jan 2023

Keywords

Cerebral vascular disease
Dementia
Small vessel disease
Vascular cognitive impairment
Vascular dementia

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience
Clinical Neurology
Biological Psychiatry
Behavioral Neuroscience

Online availability

10.1016/j.cccb.2023.100189License: CC BY

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Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C. C., McColl, B. W., Castro, B. D., Webber, C., Reyes, C. A., Hall, C., Lawrence, C. B., Hawkes, C., Pegasiou-Davies, C. M., Gibson, C., Crawford, C. L., Smith, C., Vivien, D., McLean, F. H., Wiseman, F., ... Wardlaw, J. M. (2023). A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition and Behavior, 5, Article 100189. https://doi.org/10.1016/j.cccb.2023.100189

Sri, S, Greenstein, A, Granata, A, Collcutt, A, Jochems, ACC, McColl, BW, Castro, BD, Webber, C, Reyes, CA, Hall, C, Lawrence, CB, Hawkes, C, Pegasiou-Davies, CM, Gibson, C, Crawford, CL, Smith, C, Vivien, D, McLean, FH, Wiseman, F, Brezzo, G, Lalli, G, Pritchard, HAT, Markus, HS, Bravo-Ferrer, I, Taylor, J, Leiper, J, Berwick, J, Gan, J, Gallacher, J, Moss, J, Goense, J, McMullan, L, Work, L, Evans, L, Stringer, MS, Ashford, MLJ, Abulfadl, M, Conlon, N, Malhotra, P, Bath, P, Canter, R, Brown, R, Ince, S, Anderle, S, Young, S, Quick, S, Szymkowiak, S, Hill, S, Allan, S, Wang, T, Quinn, T, Procter, T, Farr, TD, Zhao, X, Yang, Z, Hainsworth, AH & Wardlaw, JM 2023, 'A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia', Cerebral Circulation - Cognition and Behavior, vol. 5, 100189. https://doi.org/10.1016/j.cccb.2023.100189

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title = "A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia",

abstract = "Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.",

keywords = "Cerebral vascular disease, Dementia, Small vessel disease, Vascular cognitive impairment, Vascular dementia",

author = "Sarmi Sri and Adam Greenstein and Alessandra Granata and Alex Collcutt and Jochems, {Angela C.C.} and McColl, {Barry W.} and Castro, {Blanca D{\'i}az} and Caleb Webber and Reyes, {Carmen Arteaga} and Catherine Hall and Lawrence, {Catherine B.} and Cheryl Hawkes and Pegasiou-Davies, {Chrysia Maria} and Claire Gibson and Crawford, {Colin L.} and Colin Smith and Denis Vivien and McLean, {Fiona H.} and Frances Wiseman and Gaia Brezzo and Giovanna Lalli and Pritchard, {Harry A.T.} and Markus, {Hugh S.} and Isabel Bravo-Ferrer and Jade Taylor and James Leiper and Jason Berwick and Jian Gan and John Gallacher and Jonathan Moss and Jozien Goense and Letitia McMullan and Lorraine Work and Lowri Evans and Stringer, {Michael S.} and Ashford, {M. L.J.} and Mohamed Abulfadl and Nina Conlon and Paresh Malhotra and Philip Bath and Rebecca Canter and Rosalind Brown and Selvi Ince and Silvia Anderle and Simon Young and Sophie Quick and Stefan Szymkowiak and Steve Hill and Stuart Allan and Tao Wang and Terry Quinn and Tessa Procter and Farr, {Tracy D.} and Xiangjun Zhao and Zhiyuan Yang and Hainsworth, {Atticus H.} and Wardlaw, {Joanna M.}",

note = "The workshop upon which this paper was based was supported by the UK Dementia Research Institute, Dementia Platforms UK (DPUK1: MRC grant MR/L023784/2: UK Dementias Research Platform; DPUK2: MRC grant MR/T033371/1: MICA: Dementias Platform UK 2 – Integrated Dementia Experimental Medicine), British Heart Foundation and Guarantors of Brain. The UK Dementia Research Institute receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer{\textquoteright}s Society and Alzheimer{\textquoteright}s Research UK.",

year = "2023",

month = jan,

doi = "10.1016/j.cccb.2023.100189",

language = "English (US)",

volume = "5",

journal = "Cerebral Circulation - Cognition and Behavior",

issn = "2666-2450",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

AU - Sri, Sarmi

AU - Greenstein, Adam

AU - Granata, Alessandra

AU - Collcutt, Alex

AU - Jochems, Angela C.C.

AU - McColl, Barry W.

AU - Castro, Blanca Díaz

AU - Webber, Caleb

AU - Reyes, Carmen Arteaga

AU - Hall, Catherine

AU - Lawrence, Catherine B.

AU - Hawkes, Cheryl

AU - Pegasiou-Davies, Chrysia Maria

AU - Gibson, Claire

AU - Crawford, Colin L.

AU - Smith, Colin

AU - Vivien, Denis

AU - McLean, Fiona H.

AU - Wiseman, Frances

AU - Brezzo, Gaia

AU - Lalli, Giovanna

AU - Pritchard, Harry A.T.

AU - Markus, Hugh S.

AU - Bravo-Ferrer, Isabel

AU - Taylor, Jade

AU - Leiper, James

AU - Berwick, Jason

AU - Gan, Jian

AU - Gallacher, John

AU - Moss, Jonathan

AU - Goense, Jozien

AU - McMullan, Letitia

AU - Work, Lorraine

AU - Evans, Lowri

AU - Stringer, Michael S.

AU - Ashford, M. L.J.

AU - Abulfadl, Mohamed

AU - Conlon, Nina

AU - Malhotra, Paresh

AU - Bath, Philip

AU - Canter, Rebecca

AU - Brown, Rosalind

AU - Ince, Selvi

AU - Anderle, Silvia

AU - Young, Simon

AU - Quick, Sophie

AU - Szymkowiak, Stefan

AU - Hill, Steve

AU - Allan, Stuart

AU - Wang, Tao

AU - Quinn, Terry

AU - Procter, Tessa

AU - Farr, Tracy D.

AU - Zhao, Xiangjun

AU - Yang, Zhiyuan

AU - Hainsworth, Atticus H.

AU - Wardlaw, Joanna M.

N1 - The workshop upon which this paper was based was supported by the UK Dementia Research Institute, Dementia Platforms UK (DPUK1: MRC grant MR/L023784/2: UK Dementias Research Platform; DPUK2: MRC grant MR/T033371/1: MICA: Dementias Platform UK 2 – Integrated Dementia Experimental Medicine), British Heart Foundation and Guarantors of Brain. The UK Dementia Research Institute receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK.

PY - 2023/1

Y1 - 2023/1

N2 - Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

AB - Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

KW - Cerebral vascular disease

KW - Dementia

KW - Small vessel disease

KW - Vascular cognitive impairment

KW - Vascular dementia

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U2 - 10.1016/j.cccb.2023.100189

DO - 10.1016/j.cccb.2023.100189

M3 - Review article

C2 - 37941765

AN - SCOPUS:85175174079

SN - 2666-2450

VL - 5

JO - Cerebral Circulation - Cognition and Behavior

JF - Cerebral Circulation - Cognition and Behavior

M1 - 100189

ER -

A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Abstract

Keywords

ASJC Scopus subject areas

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