TY - JOUR
T1 - A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures
AU - Kizer, Megan E.
AU - Linhardt, Robert J.
AU - Chandrasekaran, Arun Richard
AU - Wang, Xing
N1 - Funding Information:
M.K. and A.R.C. initiated the discussion and designed the paper. All authors contributed to the manuscript preparation. X.W. appreciates supports from Rensselaer Polytechnic Institute (RPI) new faculty startup funds, RPI-CBIS Facility Award, and HT Materials gift fund. M.K. thanks the support from Slezak Memorial Fellowship.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/6/26
Y1 - 2019/6/26
N2 - Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA-based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed “properties” and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode.
AB - Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA-based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed “properties” and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode.
KW - biocompatibility
KW - cellular internalization
KW - DNA nanostructures
KW - drug delivery
KW - stability
KW - targeting
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U2 - 10.1002/smll.201805386
DO - 10.1002/smll.201805386
M3 - Review article
C2 - 30985074
AN - SCOPUS:85064489471
SN - 1613-6810
VL - 15
JO - Small
JF - Small
IS - 26
M1 - 1805386
ER -